There is not a linear relationship between the grid bias value and quiescent dissipation as a percentage of maximum. 0.5 is roughly 66% IIRC but I'd have to run the numbers again to be sure.
With a real tube amp there is no hard-and-fast rule. Some say 60%, some say 70%. But that's a simplistic view of the problem. The optimum value is dependent on many things: B+ voltage, transformer turns ratio, etc. For example, if the transformer is overmatched you can run the bias hotter and this is indeed how some amps are designed (i.e. Trainwrecks).
The reason for the "rule" in tube amps is to reduce crossover distortion while also preventing premature wear to the power tubes. The hotter the bias the more linear the response. However too much bias and there's the danger of the tubes momentarily operating outside the SOA which shortens tube life. Even if you stay within the SOA if you operate near the limits you'll shorten tube life. If you overmatch the transformer you move the load line and increase the SOA margin so you can increase the bias.
The Axe-Fx is immune to tube wear so there is no danger in running the bias hot if you like that sound. However the hotter the bias the less dynamic the response becomes. Also some people like a bit of crossover distortion. Legend has it that EVH liked his amps biased cold. Wether that was because of the added dynamics or the extra grit due to crossover distortion is unknown.
As always the correct answer is what sounds best.