It's a too taste kinda thing. However that's a question that can only be answered by knowing how you are using the AFX. Is it being used in a bedroom with 5" mixing monitors or on stage with an actual guitar cabinet, or with FRFR speakers. Finding the thing that moves you, makes you happy can sometimes be just an EQ adjustment to the main amp page. Or it could be excessive tweaking almost every damn setting in the amp and cab blocks. Thats the beauty and nightmare of the AFX it's all at your fingertips.
If your close it's sometimes best to just walk away. Sleep on it, take a little time to think about whats missing and how and what to adjust to get to where you want to go.
I will use myself as an example. I think most of the amp and cab combinations stock in the AFX sound glorious when playing them by myself with no other audio but them. And for the most part playing to cover tunes or backing tracks with minor EQ adjustments. My main goal with the AFX is to sound great with the band I'm in. Enter the nightmare part, My other guitarist plays a Blackstar HT-100 MKII head and old peavey 4x12 while I use the AFX III Matrix 1000 and 2 passive Xitone wedges. The Blackstar set with EQ the way he likes it in my opinion sucks ass, huge bass tons of upper mids and highs. But that is what I have to work with. Knowing that the way he sets up that amp is supposed to sound like a boogie I have set the AFX to a Recto2 Red Modern and the closest cabinet I have found factory2 5153 121F to sound like the Blackstar and his cab. I have tweaked ever perimeter in every section of the amp block as well as the cab block to get something that even resembles the Blackstar.
Anyway the point I'm trying to make is there isn't a formula that works for everyone in every situation. Naturally you want to fit the mix of media your playing with. Sometimes that can be easy other times a real PITA.