Speakers have a natural roll off, and you can't do High/low EQ cuts on a real guitar cab live, so why would you in the Axe?
I agree with you in principle and sometimes the drastic cuts people recommend are, let's say, not what I would do. Like you said, the frequency response of the real cabs, mic, mic placement, and mic pre are built into the IRs themselves. However there is a good reason to cut a little on your end: to clean up your IEM mix a bit if you're getting a pre-fx send from the monitor console. That is my preference for monitors because it drives me crazy when I can hear EQ tweaks that FOH or monitors might be doing on my signal. But I can still clean up the low end in my ears a bit by high passing at the cab block, especially if I'm mixing in a Royer 121 IR which delivers a lot of low end content. I do a very minor cut, usually 12dB/octave at 60 or 80hz, i.e. not enough where the change to the tone is audible in a band mix aside from the overall cleaned up low end. I also low pass around 12k, i.e. not affecting the core of the tone but getting rid of the fatiguing ultra high end hiss in my IEMs. On the preset level I'd never go above 100hz or below like 10k except to get a specific "effect" bandpass sound.
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