Interesting question the OP posted.
Trying to think out of the box, I would like to ask the OP a different question.
Have you tried coming out of your amp, then go into your effect units, then into your speakers?
You never know how it will sound.
Actually I have done a lot of trying to understand which effect should go where in the chain and exactly why. Parallel, in series, double loopback?
Then I noted that most of the really good presets do not match my "perfect chain".
I tried fixing them, but then didn't sound as good. And as most things in life, I determined that actually trying something and experimenting was
much more productive my exhaustive mental masturbation.
Medium Spring Reverb or Medium Room Reverb?
Reverb before cab block or after?
There is no correct answer. You try it and find the sound that works best for you.
No matter what preset or chain config, their is a guy on YouTube name "
Bergs" that kicks my ass, hard!
I quit worrying about things like the perfect chain, the proper reverb, and now I focus on playing and enjoying all the awesome sounds this unit can make.
I struggle to listen to some of the metal stuff, but we all like something different, and Axe-Fx can do it.
Don't over think. Play!