I max out the output volume on the AX8, which gives me approx the same volume as plugging straight into the amp. My gigs this past weekend went great. I didn't hear any hum on this particular stage. The AX8 was plugged into a different wall (and potentially a different circuit) than the guitar amp. But no discernible hum, granted it's a loud and packed venue, very large with high ceilings, but I couldn't make out a hum.
I didn't really have time to experiment on stage, it was all business at that point. I left my amp eq settings where I left it from initial A/B comparison at home and the unit sounded great. The band loved it, and the sound guy said it rocked.
This coming weekend one of the venues I will be trying out the amp modeling with no guitar amp, so I'm looking forward to testing that out. I'll get the sound guy to crank my monitor a bit so I have some stage volume. Normally the band does not have any stage monitoring at all with our IEM rig.
I appreciate everyone's feedback. I'm just gonna keep using it and tweak things as I go and look for patterns and reasons why I perceive differences in my amp sound. But the bottom line is, it kicked ass over the weekend, and I love the small profile pedal board and scene capability. I feel like the amp gain dynamics when I adjust my volume are spot on and that's the important thing to me. Definitely sold on it after two shows. I'll update the thread if I learn anything new regarding this subject.