I play in a cover band and In my head one preset per song seems cool but In reality, i'm set up so buttons 1-4 represent clean(1), slightly driven(2), more heavily driven (3) and lead (4). Top buttons all control effects, usually chorus, phaser, delay, and an auto wah (we only have 2 songs out of 40-50 per night that use a wah so I like the auto wah for ease of use and set up.) On occasion I will swap out an effect control for another preset if e have a song requires something unusual (like livin on a prayer) but I usually find a way to have our other guitar player, who also uses the Ax8 cover those parts. As a result his set up is more of a hybird with handful of song specific presets but mostly using the same 3-4 like i do.