The best thing to do when starting out is to use all of the basic controls for the different blocks like you would on the real life amp head or effect pedal. That will get you 95% of the way there. I rarely ever touch the advanced settings and I've gotten the best tones I've ever played.
So for example:
Amp block: drive, bass, middle, treble, presence, depth, and master volume. Just use those. Try the Fat, Bright, Boost, and Cut switches, too. These are all on the Basic controls page.
Drive block: Gain, Volume, Tone.
Delay block: Time, Feedback, Mix
etc. etc. etc.
Also, this is a fantastic website to get started that was created by a forum user:
https://axefxtutorials.com/
A lot of folks get intimidated with the Axe FX because it has a lot of advanced features and a bunch of weird fancy jacks on the back. All of those things are there so it accommodates users from hobbyists to professionals. Use only what you need. If you need to use an advanced feature or want to use a computer to change your patches via MIDI and sync with MIDI clock, or just want to jam out with some headphones on, it's all there. Just use what you need and ignore everything else.