I use my Axe Fx 3 and FM9 in three different configurations- I do use it for modeling and direct tones at church and for quiet practice, but this isn't the majority of my use. Most of the time (probably 70% of the time), I use 4CM with my Tucana 3. Sounds crazy good, and I really love being able to patch other effects through the second loop. The rest of the time, I use it as a pedalboard for a w/d/w Swart rig. I run into the Axe, out to a Swart SST-30 which takes a line out of a Tone King attenuator, back into the Axe, through time based effects, and then stereo out to a Swart Stereo Master 20, for the stereo wet tones. The SST-30 has much more gain than the SM20, so it handles gain duties, and the stereo amp handles wet stereo effects.
I once messed around with the Tucana in a w/d/w with my Matrix power amp handling stereo duties- also worked well, but 90% of my use to the Tucana and Swart rigs.