not really touching the ADV parameters to get the sound I want with these amp sims.
then again, warm and organic aren't really what I look for in a good metal patch, but this stuff works well in context:
PVH5105
Drive 5
Bass 2.01
Mid 1.5
Treble 9.02
Pres 9.06
Master 2.01
4x12 German + U87
(Cab Drive 3.54, or not, your choice)
add a PEQ or filter,
shelving(!), 88Hz, Q1.122, -12dB
adjust frequency for your down tuning needs.
the filter adds a nice bump at the cutoff frequency while removing low end mud at the same time - you probably have to play together with your bass player to find the sweet spot.
removing some mids also helps:
peaking, 467Hz, Q2.315, -5,76dB
and
shelving, 6.1kHz, Q1.122, -6dB (this will clean up the high end, adjust cut to taste)