PRS: I've gotten this issue at all times with certain pups. Active pups will bring it on even more. For me, all my guitar pre-amps behave in this manner when at close range. Let me tell you, my studios are wired so tight and so clean, there's no doubt in my mind it's your pups on that particular guitar and it is NOT a grounding issue. Certain guitars hum more than others when facing outboard gear. You have 6 possible fixes:
1. Turn away. I know you know this and it seems obvious, but it's really one of the easiest fixes. I've done the "turn away" method for years. It didn't matter if I used a 2101, a Tri-Axis, a Mesa recording pre or my AxeFxII. When I face the rack with certain guitars, it's just going to hum. Other guitars, little to no hum depending on the pups. But active pups....almost as noisy as single coils depending on how much gain is used.
2. Move your rig out of the room if you're recording and use your pedal board or Axe Edit.
3. Any chance your monitor on your pc is causing some noise? Try turning it off and see if the noise goes away or lessens.
4. You can try one of those ground lift 3 prong to 2 prong adapters. Though I don't condone this, sometimes you'd be surprised on how it can remove hum. If you get the slightest bit of thunder or lightning or know in advance that a storm is coming, get rid of this plug as soon as you can. I use one with my wireless these days due to a slight hum. If I'm in a storm situation (I always try my best to power down completely while removing AC lines from the wall or I just use numerous UPS boxes with battery back-up) I just get rid of that plug and deal with a little hum.
5. If you notice this hum is volume knob related, use more noise gate. I like the classic gate more than the smart gate that is offered. The classic doesn't choke my sound as much. Also, determine that the noise comes from something gain related. For example, I'm primarily a rock/metal guitarist. So I use a lot more gain than a blues or fusion player. The high gain sounds are the only sounds that give me a little hum. That said, I'm old school and come from the days where we used to have to stomp on a pedal and shut our volume knobs off in between phrases. I'm so fast on my volume knob, it's actually kinda scary.
With that in mind, I can run my noise gate at 90. All that does is cut out hiss for me when I am not playing. If I open my volume knob and leave it open, it will feedback and hum like a banshee screaming. But because I never allow this to happen EVER, you don't even notice it. Now, if I record, it's a little tougher to be precise and of course things recording wise are more audible and unforgiving. In that situation, I run my gate up higher so that I CAN leave my volume wide open. If I don't do this and try my old school tactic of shutting down the knob, though I have it down pretty good, it's too easy to cut something short. So my fix is to leave the knob wide open to where the gate kills any hum or additional noise.
From there, I just mess with the gate and get it as close as I can so that it doesn't choke off my sound when I lower my volume knob. It takes a little bit of tweaking to get it where you need it, but depends on how much gain you use as well as how much your pups are creating a problem. For me, I've been lucky enough to just control the threshold on the gate while never touching anything else. The stock settings seem to work really well for me as long as I use the classic gate. To kill most all noise for me, I usually end up between 80 and 70 to where it won't choke my sound. 60 something will totally kill all noise...but I get a little choking. A little tweaking with the other settings and I'd probably get that tighter too...but I always want the ability to lower my volume knob and get a lighter gain sound without the sound choking. This brings me to our last possible fix...
6. Use one of your expression pedals to lower the gain in your amp block if need be. I find that I get a better sound with my volume knob wide open and lowering the amp gain or tube screamer gain...or now thanks to a recent update from Cliff, I can control the compressor output level which is one of the main sources of gain in my particular sound. I step on a pedal, it reduces the gain and I have a clean, yet dirty sound that is right on the threshold of breaking up. It also removes all hum and noise, so again, I don't have to run my gate any higher than 90 when I play live.
So try some of this stuff out and see if it works for you. Best of luck man....and don't stress....like I said, this thing you hear has been ongoing for me for years and I have two serious studios where I do work for people all over the world. I'm wired and designed to industry standard and still get the hum you are talking about. For me it IS guitar/pup dependent.
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