Andy and Larry do it with real amps. Andy with a Mesa Lonestar and Larry with his Dumble. I've done it with real amps and my Axe-FX (and now AX8). I dropped in the Texas Star Clean amp and cab and then the drive block. In the old days (college) I had a JCM 800 50 watt that I had a MXR micro amp and a Morley volume boost pedal in front of (also a Distortion + pedal). The amp was single channel so my clean was pedals off (except chorus - it was the eighties after all ) and my guitar volume rolled back a bit. For distorted tones I hit the amp with full knob, micro amp, and if going for VH type dirt, the volume pedal boost. Worked great, but I don't miss the tap dancing or carrying the stuff.