There's plenty of good presets, and in your first day, you can just go through them, spend a few minutes on each one and write down your favorites. My issue is usually that I almost never want the effects, but many of them have a "dry" scene, and even if they don't you can always turn individual effects off or on. To get a sense of my taste, I come from an alt rock background in my playing, though over the last 10 years have gotten more into soul and blues. I play 24.75 scale P90 or PAF guitars for the most part, other guitars/pickups (and another individual's playing!) should bring out the qualities of different amps and presets.
Some of my favorites that are "normal" amps (saving crazy effects patches for last):
023 - Friedman BE-100
Sounds fantastic out of box for me, cleans up well with guitar volume. I think I use the 2018 HBE scene most.
028 - Vibrato Deluxe
There's a ton of great Fender stuff to choose from, on the preset menu this one stuck out to me (personally like the 2x10 cab).
035 - Tucana
One of my favorites all around, beautiful clean and plenty of gain (there's a second Tucana preset as well, 098).
040 - Buttery
Made it to my final 4 top cleans in the FM3.
046 - Royale with Cheese
This one is disgusting, sounds like the end of the world, fun stuff.
050 - JTM 45
Go-to Marshall for me, cleans up pretty nice with guitar volume.
071 - Bassman about 2 Explode
As fun as it sounds.
074 - Dizzy VH4
The Diezel preset has a good scene-by-scene step up in gain, and sounds great if you like to play heavy.
085 - Try Axes
Based on Mesa Tri-Axis, sounds good for me with minimal/no tweaks. I like it because it has one of the cleaner clean scenes in a preset that also has a nice higher-gain scene.
226 - Class-A Lineup
If you like Vox-ish sounds (who doesn't), this is a good place to start because it pulls together several of the options from the FM3 that can do that sound, once you pick a favorite you can go to that particular amp's preset, or of course make your own.
Crazy/fun stuff, the higher number presets feature a lot of extreme effects that are worth checking out and studying from a signal routing standpoint to help you learn how to get what you need. Just a couple favorites:
128 - Galaxy Formation FM3
If you like Sigur Ros, this does an awesome job of recreating the bowed guitar with heavy reverb sound from their records. The scene with no dry signal does the best job of this.
154 - Bl@de run liter (EMI)
Come on, this is just pure fun.
168 - Crystal Echoes
One of many shimmering ambient sounds.
187 - Verb->Trem
Very musical and usable for a heavy effect.
192 - Diffused Phaser
Just sounds nice to me.
228 - Synth Lineup
For something completely different.
Also try everything that says "FAS" on it (hint: Fractal Audio Systems, these are their custom amps).