No.
A lot of IR's were captured with neutral test microphones. The mic sims are a way of EQ'ing an IR and were born from those "neutral" IR's.
Today, the overwhelming majority of IR's are captured with close microphones setup like conventional close mic guitar tracking in a studio. As such, the microphone is "baked in" to the IR's.
The default for the mic sim is "None" because of this.
Disabling or enabling the mic sim will not make a preset sound like an amp in the room because the IR's are captured with microphones close to the speaker grill. The mic sim can't change that.
Understood thanks for setting me straight! (;-}