I have no idea what the issue could be. Watching this space in case you solve it...but... Have you tried removing the file: Library/LaunchDaemons/com.fractalaudio.axefx2load.plist? or...have you inadvertently changed the status of the FAS launch agent? I use CleanMyMac software and remember having a problem with a different app that wouldn't work until I adjusted that setting. I feel like it could have something to do with this...but really not certain. Also, have you tried setting it up on another system or under a different user account on the same system to see if you have the same issues?