I've owned a couple of Strats (vintage reissues and modern) and a G&L (S-500). They were all good guitars, but different.
The vintage Strats have a very curved fretboard radius (7.25"), and vintage (tiny) frets and vintage pickups. So you're not going to get the action too low, and you'll get some 50/60Hz hum.
The other Strat had a 9.5" radius and medium frets (as well as locking tuners, a 2-point tremolo and Lace sensor pickups). So, this guitar was much easier to play, quieter, and easier to keep in tune.
The G&L had a 12" radius and jumbo frets and slightly thinner neck profile. Modern feel, easy to play and sounded really good.
As far as sound goes - they all sounded like a "Strat" (3 single coils and a 5 way switch). I played all of these before I bought them, so everything was in order in terms of tone, build quality , etc.
I would say try a couple of variations out, and see which one sounds/feels best to you. Whatever you decide, I'm sure you'll be able to cover those Strat tones convincingly.
If you're not sure what radius is, it's the curvature of the fingerboard. A lower number is more "rounded", a higher number is "flatter". Don't confuse this with neck profile, which is the back of the neck