plugging into left will give left signal only. That may be fine a many presets. It may not work for some that use heavily panned stereo effects. You can set the the output copy L to R (same as pluggin into the left only the right out is just a copy of the left. Or you can select sum L+R (it takes both signals, mixes them together, and output them on both channels). With this option you have to worry about phase issues. If the Left and right signals use any effects that may change the phase of one signal to the other, it can really mess with your tone. For example, if you use the default settings on a 2290 delay, one side of the delay is 180 degrees out of phase the with the other. In stereo this sounds huge. In mono, the delays cancel each other out and you get 0 delay level.
The classic enhancer will also cause phase issues (comb filtering effect). So you need to check your patches for mono compatibility (switch between stereo and L+R or copy L > R) to be sure then correct any anomalies going from stereo to mono.
Look for any effects that have phase reverse (delays, modulation) plus the enhancer. They are the ones that can cause the greatest issues.