So far I've decided to go with Layout 7 (PERFORM1) as my home.
I put scenes 1-5 on Buttons 1-5; Amp level +2dB (tap), -2dB (hold) on Button 6; shortcuts to Layouts 1-3 (PRESETS, SCENES, EFFECTS) on Buttons 7,8,9; Preset +1, Preset -1 on Buttons 10,11; Tuner on Button 12.
My PRESETS, SCENES, & EFFECTS Layouts are as you'd expects except I make sure I have an Amp level +2dB (tap), -2dB (hold) and Tuner buttons on SCENES & EFFECTS Layouts and most importantly a shortcut button back to Layout 7 (PERFORM1) on each of the other 3 layouts.
Brightness variability is good but you're not going to be able to resolve individual LCDs if your vision is poor without glasses.
The setup for the FC on the Axe III is excellent, intuitive and easy to customize to your individual needs.