I've considered going that route and it looks awesome, but to me, it feels pricey on top of the expensive amp. Also, just so many patch cables. I'm sure good custom cables will be super reliable but prices/weight just add up. I feel like the switcher thing is perfect for folks that are in love with their particular pedals, which I am not. Looking to get more complex tonally, but simplify the actual rig. I care a lot about good tone, but I'm not married to any of my particular pedals so I feel like Fractal's effects would be just fine for what I'm after. The main effects I use are:
Delay (short, medium, long, and washy sound)
Reverb (normal, and super wet washy sound)
Octave Down
Octave Up
So switching between all that stuff while trying to nail the downbeat of a chorus can be a pain. My board at the moment is:
In front of the amp: Polytune > Diamond Compressor > Micro POG > BB Preamp > Phase 90 > Boss NS-2 Gate
In the loop: Boss CH-1 > Boss DD-500 > Hall of Fame Reverb
90% of the time it's the drive channel of the BE-100 and some light delay. Anyways, just sort of thinking out loud here.