I used to turn as little knobs as possible when I was running through an actual amp head and cab. But since I changed over to direct, the first thing I noticed was that I had to turn down the high cut and turn up the low cut on the amp block. I recently have been doing the same on all the other effects in the chain to match the amp settings. Seems to really tighten it up on my setup. I'm just curious if you do the same.