Latest medical work targeting noise induced hearing loss

If it can’t help restore the function of the damaged outer hair cells in the cochlea I’m not sure how it would really restore that much hearing sensitivity.

seems to be they are missing a basic understanding of cochlear physiology, or at least the tv news website that reported it didn’t do so very accurately.
 
If it can’t help restore the function of the damaged outer hair cells in the cochlea I’m not sure how it would really restore that much hearing sensitivity.

seems to be they are missing a basic understanding of cochlear physiology, or at least the tv news website that reported it didn’t do so very accurately.

I think it's the news Web site that has simply put a spin on it. No mention as to what the drug actually is, how it works, or how it is magically going to regenerate nerve endings and connections to hair cells, or even re-grow hair cells that no longer exist. You'd have to forgive my skepticism on this one.

EDIT: This, from University College Hospital in London in the UK may perhaps be a bit more relevant and likely. It's not a magic tablet, but an injection, and MAY, just MAY, be a goer. This one DOES target regrowth of hair cells:

https://www.uclh.nhs.uk/News/Pages/Newdrugcouldrestorehearinginthedeaf.aspx
 
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seems to be they are missing a basic understanding of cochlear physiology, or at least the tv news website that reported it didn’t do so very accurately.
I think it's the news Web site that has simply put a spin on it. No mention as to what the drug actually is, how it works, or how it is magically going to regenerate nerve endings and connections to hair cells, or even re-grow hair cells that no longer exist. You'd have to forgive my skepticism on this one.

If you want to look into this further, feel free to call them and review their publications.
https://houghear.org
https://houghear.org/research/
https://houghear.org/publications/
 
If you want to look into this further, feel free to call them and review their publications.
https://houghear.org
https://houghear.org/research/
https://houghear.org/publications/

I don’t know..... it all reads kind of questionable to me.... asking for money everywhere, “we need your help”, etc kind of stuff.

also given the outer hair cells are the ones commonly damaged by noise, and the resulting loss of electromobility and “cochlear amplifier” effect which gives us sensitivity for softer sound sensation, it’s a bit odd they are only talking about inner hair cells, which generally are quite intact and robust in most people with typical hearing loss.

it would be great to restore inner hair cell function, don’t get me wrong, but without the outer hair cells, your not really hearing much typical softer sounds and I just don’t see exactly what their research is getting at exactly

They’ve apparently been so very “close” for years now too, and it’s talways “need our help”

https://www.tinnitustalk.com/thread...-institute-needs-our-financial-support.31301/

Just doesn’t seem quite kosher to me honestly. Tinnitus “cure” etc would be worth billions of dollars. If they really were “close” surely one of the big pharmaceutical companies would be buying the rights and helping move it through the FDA trials etc.
 
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I don’t know..... it all reads kind of questionable to me.... asking for money everywhere, “we need your help”, etc kind of stuff.
That’s what non-profits do. Feel free to read their research and decide yourself. I just put it out there as a resource if anyone wants to look into it.
 
That’s what non-profits do. Feel free to read their research and decide yourself. I just put it out there as a resource if anyone wants to look into it.
I think the one in my link above, from University College Hospital in London, has a bit more credibility...

EDIT: The fund-raising aspects don't worry me - our hospital research institute does the same. And I've just checked some of the publications on the topic from their Web site. It's actually not that different from the University College Hospital research in London, but the ability to achieve regrowth using oral medication is something that I have my doubts about. However, as always, time will tell, and if either the Hough mob or the UCHL mob turn something up that works, then the world will be a better place for many.
 
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When i
I work for Johns Hopkins. This stuff is completely normal and par for the course.

when I was at the OSU James Cancer hospital there was also plenty of request for donors too, but it never was such a blatant “we are close to curing cancer but can only do it with your help” vibe.

it just looks like they’ve been saying the same thing for years now, there have been no human trials, just lab and animal tests (and certain animal species such as avians can already regenerate hair cells).

i respect the fact they are working on things, but at the same time, I think one needs to be careful of funding work that is always “close”....

it’s like if you had a kitchen remodel and the contractor keeps saying “almost finished” for months after months while continually needing more money to finish the job......

basically, I’ve seen so many empty promises and “snake oil” treatments pitched to tinnitus suffers, and many are desperate so they spend a lot of money on ineffective “cures”.

I once had a patient who sold his car to get money to go to Europe for transcranial magnetic stimulation because he read it could help, and of course it didn’t, nor had it been proven to, but they gladly took thousands of dollars from him and of course said he needed more sessions which he couldn’t afford, so then I ended up with a patient who not only still suffered tinnitus, but was more hopeless than ever as yet another thing didn’t work, and he was also now financially in the hole, making matters worse.

I just don’t want to see folks give these guys thousands of dollars thinking a breakthrough is going to suddenly happen and they will be cured. Even if they are close the time frame for FDA human trials takes forever so no one would be seeing anything for quite some time.

again, one can freely donate how they see fit, to whomever they want, but do some due research before making contributions.
 
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