You can cramp a lot in a preset by designing a preset smart. For example, the grid below requires between 80-90% CPU.
COMP: the ""Pedal" compressors require less CPU than the Studio type. In this preset a Studio Comp is used.
PEQ: the first PEQ has the low-cut and high-cut characteristics of a "clean boost" Klon Centaur. It isn't the same as a Drive block but it requires a lot less CPU than a Drive.
PHASER, FLANGER, DRIVE, DELAY: all using X/Y. Also note that some Drive types take up more CPU (up to 4% more) than other types.
AMPS: I don't use the advanced stuff. Example: using OUT COMP increases CPU usage (depending on its setting).
CAB: I'm using UltraRes, mono. Saves CPU when compared to stereo. When I want to use multiple IRs I mix them into a single one, using Cab-Lab (to be released soon). A Mono cab suffices because all my stereo stuff comes after the Cab. Also, I'm not using the preamp simulation, saving CPU.
REVERB: I'm using the Spring Reverb. It has no High Quality mode, but it has been improved some firmware revisions ago and sounds awesome with my clean and lead tone tone. The Spring requires not nearly as much CPU power as other reverb types. If I need a specific other type of reverb I put in a dedicated preset.
The noise gate in the Input/Gate block is off, saving CU again.