Put it in a loop, or pre the Axe.
Use the Tube Pre block as a tube power amp sim, by...
...taking the speaker, power amp, power supply, and power tube parameters of a tube amp you desire, and type them into the Tube Pre.
Also, I set the input trim to .5 so I won't hit the front end of the Tube Pre block too hard, and adjust the power amp trim as desired to hit the virtual tube power section as needed.
Set an impedance curve for your cab block's IR, and adjust the presence, depth, and master volume as needed
That's the authentic way, and of course you have the dynamics and EQ etc to use as needed too.