Mainly 4 for gigging (Vibroverb-clean, Maz 38-dirty clean, Marshall Silver- Crunch, Soldano SLO- High gain lead). I also have a null filter on the first 3 so I can boost any of them for a lead tone, as well as a Lovepedal Eternity on the Dr Z for a classic rock lead sound. It's pretty straight forward with the MFC controlling it.
I do some fun stuff at home with my Mesa Nomad 4x10 and an Analogman King of Tone pedal, which I am going to take a shot at replicating on my Axe FX. There's no KoT pedal there, but I should be able to come close with two drive pedals in series... which is essentially what the KoT is. Awesome pedal, if you haven't tried it.
That's for live stuff. I play with bunches of presets at home. The versatility and quality of sound is amazing sometimes. A used-to-death word these days, but fits accuarely here.