I use Ableton. If you are planning on using the Focusrite as teh interface and simply want to use the Axe as a DI, you have to go from one of the outputs of the Axe into an input on your interface. So for example if you are using Input 1 on the focusrite to bring in the Axe signal, you need to first go to Ableton Preferences and chose the Focusrite as your input and output source. than once you have, you need to add an Audio Track. Arm the Audio Track, make sure that INPUT MONITORING is on. than choose input 1 as the input source. you should see signal and hear sound coming from the Axe into your Interface and out of your headphones/monitors. If you don't than you are not getting any level on the Axe. That is likely the culprit. If you have signal from the axe FX when plugged in directly, that means that it is sending audio. That audio is no being sent to INPUT1 on the interface and you should be good to go.. let me know what happens. i am a Power user for Ableton.