Genome's suggestions are a great place to start. I would add that your best bet would be to pick one cab block to work with (and one amp if you can). The Cab really colors the sound arguably more than the amp. That's another discussion - but if you could reduce the variables and pick a single amp block and a single cab block to work with, then you can zero in on your desired tone.
If you can't crank up at home, then use a fairly decent set of headphones and dial in a sound. At rehearsal, crank that puppy up real quick, play a couple of open chords, a couple of palm mutes, a couple of high notes. In seconds, you'll know what you need to do. Even if you don't know much about EQ, start with the EQ settings Genome listed and adjust that.
Don't forget to reassess when the band is playing - if you're not cutting through, add mids. ...or cut highs and extreme lows. Get in there and mess around - turn some knobs!
Adjust the amp settings. You can't go wrong. If you like it better, save it. If you don't, then don't save. No risk.
I personally cut the bass at the cab block - high pass at 80 cycles. I use as few cab blocks as possible per show so that it all sounds uniform in the house.
Good luck, man!