I know Reaper lets you mix/match sample rates...Don't expect it.
Most DAWs do on the fly conversion, otherwise you can use Asio4All
Ok. So let's say you record guitars with Axe at 48. How to you proceed if you need to use a different DAW at 44,1 for vocals?
Well the reason for me is that my Focusrite soundcard to record vocals is in 44,1
Would the best be to go from the Axe via the Focusrite?