I have used various setups with my former FM-3, and now my Axe-FX III.
Average venues: (not small bars, and not large outdoor stages)
I run an out with a cab block to FoH. My stage setup is a out before the cab block that runs into a Fryette PS-2 and 1x12 Mesa Rectifier slanted cab.
Small bars or other venues with cramped space:
I use outs with cab sim to FoH (if extant), and to an LD Systems MON G3 8". This is small power floor wedge with a tremendous vertical throw, which is very helpful when I am only standing a couple of feet in front of it.
Large outdoor gigs or festivals:
Depending upon the quality of what is provided, I will either just give them an out for FoH and get a good monitor balance, or use a LD Systems ICOA 1x12 powered speaker. The reason for both scenarios is setup and turn-around time.
Being a multi-instrumentalist who also plays keys, I have never considered an FRFR specifically for guitar to get a good use of funds for me.