Live, using a traditional rig, you are forced to compromise unless you slave your amp and re-amp.
In the studio, the normal signal chain is:
Guitar>wah>OD pedal>amp>speaker cabinet>time based effects
Live with no effects loop in the amp, you have to put all pedals before the amp and live with it.
Live with an effects loop you place the time based effects within the loop.
Pro-rigs of the 80s and 90s slaved their amp head down to line level, turning their 100 watt head into just another pedal essentially. That would look like:
Guitar>wah>OD pedal>slaved head>time based effects>stereo power amp>cabinets
Those wishing to retain some dry 100% analog added a third cabinet and "tri-amped", the ultimate refrigerator sized rack system. Those of us who were completely over the top slaved multiple heads. At one time I had a Mesa Road King, a Diezel VH-4, and original 5150 wired to access all three channels and a single channel fourth head I rotated in and out. So I had eight amp channels to choose from, which for the day was leading edge.