I think it is totally worth it in some applications. Actually, I don't get why anyone would care how much CPU is being used as long as it isn't choking. It's there to be used, so USE IT ALL!!!
Case in point... I was looking for a great blues tone that would go from clean to scream with just volume knob adjustments. I used to achieve this in the real world by running a 65 Twin and a tweed Super together. I got the "tone" from the Super running hot and dirty and ran the Twin clean with the bass and treble up to give me some added punch and attack.
Translating this into the virtual world was simply a matter of creating a clean Black Face amp and cab setup and getting it to sound right, then adding a Brown Face amp and cab setup in parallel, pushing the drive, and pushing the mids with the bass turned way down. From there, I added tremolo and reverb blocks to the Black Face side and a delay block to the Brown Face side. Stuck compressor and drive blocks in front of both of them before the parallel split, and I have enough tonal candy to keep me busy for hours with just one patch! The CPU meter tells me it is sweating, but it handles it just fine.