Can you Fix Output 1 at a preset level?

I found that pegging the Output 1 knob to 100% then reducing global EQ gain to -12 and then reducing input trim on my X32 to -2 gave me the same volume I had previously. Next question. Are there any audio quality issues with maxing the gain in one area (Output 1) and reducing it to max in the other (EQ global gain).
 
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