When it “stops working” what actually happens, does Axe-Edit lock up or does it appear that everything is working but the connection just drops? Are you actually uninstalling the drivers and re-installing them or just re-installing them without uninstalling them first?
My recommendation would be make sure the Axe-Fx II is not connected and try uninstalling the drivers and removing any unknown devices in Device Manager. Once the drivers are uninstalled and the devices have been removed, reboot your computer. Try installing the drivers again following the installation instructions and using one USB port; don’t keep switching to different ports. Once the drivers are installed, try running it and see if it works. If it stops working again and you end up with an “unknown device” in Device Manager, try manually updating the drivers for the unknown device. Right click on the “unknown device” and select “Update Driver Software…” the select “Browse my Computer For driver software”. Select the location where the drivers are installed. It should be “C:\Fractal Audio Systems\Axe-Fx II USB Driver Installer\Driver”. Once the driver is finished updating, try running it and see if it works, if it does I would try to make sure you always use the same port because Windows may try to re-install the driver again if you use a different port. If it appears that it is working after a while, try disconnecting the Axe-Fx II again and rebooting your computer. Then try connecting the Axe-Fx II again and see if it works or if it tries to re-install the driver again. If it tries to re-install the driver again and you end up with another “unknown device” you may need to repeat the manual driver installation.
Something else to check would be to make sure that the computer is not allowed to turn off the device to save power. It’s possible this could be causing the disconnection if there is some idle time during use. In Device Manager right click on your USB hubs, select “Properties” and then the “Power Management” tab and make sure the checkbox for “Allow the computer to turn off this device to save power” is not checked. You may need to check this for the Axe-Fx driver too but I don’t currently have it connected so I’m not sure if it has this option or not.
Hopefully, one of these will work good luck!
My recommendation would be make sure the Axe-Fx II is not connected and try uninstalling the drivers and removing any unknown devices in Device Manager. Once the drivers are uninstalled and the devices have been removed, reboot your computer. Try installing the drivers again following the installation instructions and using one USB port; don’t keep switching to different ports. Once the drivers are installed, try running it and see if it works. If it stops working again and you end up with an “unknown device” in Device Manager, try manually updating the drivers for the unknown device. Right click on the “unknown device” and select “Update Driver Software…” the select “Browse my Computer For driver software”. Select the location where the drivers are installed. It should be “C:\Fractal Audio Systems\Axe-Fx II USB Driver Installer\Driver”. Once the driver is finished updating, try running it and see if it works, if it does I would try to make sure you always use the same port because Windows may try to re-install the driver again if you use a different port. If it appears that it is working after a while, try disconnecting the Axe-Fx II again and rebooting your computer. Then try connecting the Axe-Fx II again and see if it works or if it tries to re-install the driver again. If it tries to re-install the driver again and you end up with another “unknown device” you may need to repeat the manual driver installation.
Something else to check would be to make sure that the computer is not allowed to turn off the device to save power. It’s possible this could be causing the disconnection if there is some idle time during use. In Device Manager right click on your USB hubs, select “Properties” and then the “Power Management” tab and make sure the checkbox for “Allow the computer to turn off this device to save power” is not checked. You may need to check this for the Axe-Fx driver too but I don’t currently have it connected so I’m not sure if it has this option or not.
Hopefully, one of these will work good luck!