Since you asked for advice, I will share my highly opinionated... opinions:
1) Watch all of Leon Todd's 5-minute tones. I read the manual before the Axe arrived, but this is how I actually learned to dial in sounds. Leon tweaks what needs to be tweaked, and explains how each settings affects the sound. This IMO is much better than just being given a list of settings, or even downloading a preset, because then you learn what they all do.
2a) There are so many amps. Try one or two that you're already familiar with, and don't feel pressured to try them all. (On the other hand, try them all! Why not!) But I would pick one or two, and get really good at dialling them in, just like if you'd bought a real amp. That way you learn more of the subtle changes you can make.
2b) IR choice can also be a bottomless pit. My advice? Pick one and stick with it until you're more comfortable with dialing in sounds. A lot of us like LT TV Mix 7, which you can get off AxeChange. (Again from
@2112). Just use that for everything for a while.
3) Keep it simple while you're learning to dial in sounds. Amp+Cab, maybe some reverb and delay. Stick with what you'd find on a typical amp - gain, bass/mid/treble, etc. Don't worry about the advanced parameters yet, many people have no need to touch them (and most of us don't understand them!) (Unless of course you understand what cathode follower harmonics are, in which case, knock yourself out, and then teach me.)
4) Try to play loud. How loud? 90dB, since I'm being opinionated. The Fletcher-Munson effect is real, but besides, it just sounds better loud. (But don't hurt yourself!)
5) Think about your sound output. There are infinite opinions on this, but the axe, like anything, will sound bad through crappy speakers. It's magic, but it's not
that magic. I use some relatively cheap studio monitors (Presonus Eris E5) and Shure SE215 for live in-ear monitoring, and they're good enough for me. Others like FRFR solutions like QSC monitors, which I use at one venue and like the sound. Others prefer a real guitar cab and poweramp. Whatever you choose, cheap headphones will sound like poop. This can be another rabbit-hole, but my opinion is that good enough is good enough, although it
does have to be good enough.
6) Presets downloaded from AxeChange, or even videos on YouTube, will probably not sound the same for you. Don't worry, your Axe isn't broken. Different guitars, fingers, and monitoring solutions all interact to create a different sound. Don't be afraid to ask for help! Which lead to...
7) Use the forum! It's awesome, and you will get lots of snark-free help, often from some very skilled and experienced folk. To get the best help, put the question in the title (not just 'help'), and upload your preset. For bonus points, add a link to a clip of the sound you are trying to achieve. (For super-duper bonus points, record a raw track of your guitar, which helps people tweak exactly as if you were playing in their house. But not many people do this.) I have learned more about amps in a couple of years on this forum, than I did playing a real amp for over 20 years.
8) There's a Klon.
I did feel embarrassed and like a noob 
At least after that I have always remembered to check my wah pedal...
