after nearly 3 years with my Axe FX II, and a pair of CLR active wedges, I've come to find that the main thing is that one uses the same system to dial in your tones with, at gig levels, and that one keeps using the same system consistently. Don't dial in on one system and then gig with another.
As for the actual choice.... there is no best. You need to decide on a setup that will work for you (ie wedges vs cabinets, powered, weight, size, application) and then price. There are tons of options, you need to shop around.