And ofcourse another thing is that we guitarists have been gigging for years if not decades with real tube amps and are used to the "sound in the room" (which is ofcourse easily possible with the Axe-Fx and a cab and power amp) but personally I hadn't really been gigging for a long time before getting into modeling so I much prefer the studio quality tone live that cuts through and also lets me hear other band members better. Amp in the room will have a lot more low end and reverb ofcourse which are things that are hard to model and at least IMO stupid to try and model since a FOH will always have natural room/reverb qualities. Running real amps live always lead to me never hearing our vocalists and me being someone who is singing half of the lyrics anyways I can't hear myself if I have my Orange rig with me on smaller club gigs.
But ofcourse this is once again about what we're accustomed to.