It's basically my daily driver except for backups, and that's just because I have a redundant cloud-synced backup set up on my old windows pc and was too lazy thus far to configure something similar on my linux machine. Most of my preset editing is done from linux these days.
I've got the Axe FX connected directly via USB (and use it as the main sound card of the PC as well), so no idea how / if it would work via MIDI. PC audio worked fine out of the box in desktop applications, but some steam games would treat it as a 7.1 interface instead of using output 1 as stereo (which means sound sources were only audible from certain directions). My current solution for that is a hack as multiple "proper" fixes I tried did not work, so I ended up disabling all pulseaudio (or pipewire?) multi output presets which forces it into stereo.