There are many options, and no single one is 'the best'…it's more of what sounds but good to you and the application/venue you're designing for your situation. I have tried quite a few configurations myself, including QSC, XiTone, RCF, CLR, Matrix, and 4CM to a Marshall amp+cab, to a small combo. Over time, I've narrowed it down to a few 'rules of thumb' and condensed my gear down to a few options. First, if you're playing through a PA, it does not matter how much 'rig' you have on-stage; your guitar sound will be exactly as played through the PA speaker, so best to create and tweak it through the closest speaker type….ie, if your band uses QSC tops, fine tune your patches through it. I've even gone to a rehearsal studio just so that I could play through a specific model. Second, what you hear on stage is not what the audience hears. Yes, it might give you inspiration or 'vibe', but if your sound sucks in FOH, no matter how good it feels on-stage, the audience won't hear it. Thus, once I configure and adjust my patches for FOH, my on-stage advice is keep-it-simple and avoid tons of equipment and weight…use the house monitors or in-ear monitors, or bring a small FRFR (XiTone, K10) or what I've been using lately, a Power Engine…it's small, reasonably priced, gives a decent vibe, and as added benefit, it works great in the rehearsal room. I'm now the first to load-and-go, and I don't have to 'break my back'.
Last night I did an Acoustic Trio, where I play various parts including all the leads. My first gig with the AX8. Ran direct to FOH and used the Power Engine for a touch of stage ambience. Hardly anything for me to carry and/or pack-up, and the sound was fantastic.[/QUOTE