So I'm going to throw out my recent experience.....
Start out with - I'm a fractal lover and gig with my FM3 every weekend (and have been gigging with Fractal since my first Axe Ultra purchase). That is for band gigs (electric).
For acoustic gigs, I have a small pedal board -> Keely Comp - Boss Eq - Wampler Tunmus - HX Stomp (for tuner and volume boost).
I set up an A/B box and tried to match this set up in my FM3. I tried like hell, and I cannot get as warm of a sound using the FM3 alone.
It left me a little frustrated to be honest. It logically does not make sense....but my ears are hearing what they hear.
I used a Comp - Tube Pre - EQ in the FM3. It just sounds thinner (no matter how much I EQ). I love to find out that there is something I'm not doing right...but for the time being, I've stuck with my 'analog' pedal board.