I'm still personally hoping for improvements to AxeEdit... that is where most of my "Wishlist" requests are. So many other products have really great sorting, tagging, cataloging . Right now I manage all of this outside of AxeEdit. Its frustrating for me not to be able to, while within AxeEdit, very quickly pull up a list of all presets with particular components or amp models etc. AxeEdit is great for working on the presets... I've not really complaints there... I'd just like to see them also have better preset and block management from the library perspective.
I'd also love a plugin version of some sort.
Not sure either of those fall into the next big thing category or not just my personal dreams. I always want the modeling to be the number one focus of course and even though there are things I would like to see evolve this platform I always choose fractal for the most inspiring and amazing tones. I kick the tires on EVERYTHING out there and my ears and fingers are never really satisfied by any other option.