So are you or are you not using CAB Sims with FR? This is the part that I have been confused with from the beginning. However, I am extremely happy with my setup, but am using CAB Sims with my "real" guitar cab, because I just don't like the tone without it. As stated before, I match my CAB sim as close as possible to my "real" cab.
I want to mention
@yek, your presets, that I have used, require minimal to NO adjustments for me. They cut through the mix better than all the others I have tried. And using yours as a template I have been able to get great warm tone and sustain, with no flubby, muddy, shrilly, piercing qualities.