I believe we've reached the time when digital is so much better than analog that it's hard to justify why not to go digital. There are so many complications with real amps that it's just not worth it for many people. I try to be as honest as possible and I did explain the weaknesses of using a real life cab live even with an iso box like in this case. Chevelle was doing their soundcheck when we were working with the iso boxes and there was no way we could get a clean signal without the low end rumble of them playing. Now imagine that when your whole band is playing and everything is interfering. One of the main secrets for a good miked guitar sound is to know which kind of space a guitar cabinet needs to be in in order to work properly. Let's just say that it's not an open space like f.ex. a stage and it's not a closed case like an iso box. So an IR shot from a cab in a studio room meant for guitar cabinets can easily sound better.
In 10 years time I just hope that the people filling the stadiums still use electric guitar.