4CM stereo with a head and matrix

Hi guys, here's a question for all amp users. i am currently running my axe2 with the matrix 1000 and 2 1x12 bogner cabs. What if I wanted to use a head (and make use of the head's preamp) with the axe in 4-cable-mode and still do stereo? could I return to the head poweramp for speaker A and to the matrix for speaker B? Is there any way I could put an amp block (mostly for power amp modeling) to the side that returns into the matrix and not colour the tone too much?
Thanks for any advice!
Cheers

Chris
 
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