hensh!n_vfs
Inspired
I used to, but I try to be careful as it could be your monitors (i.e., headphones, studio monitors) or environment. It could also be your pickups. In general, I try to be careful of making too many cuts. I look to establish 70-80% of what I want with an amp and IR. From there I will make selective EQ adjustments to taste and try not to go too crazy with any drastic adjustments. Drastic adjustments tell me I'm using the wrong amp or IR. I try to always have a reference point too, as it can lead to creating a mess that wasn't even there to begin with.
Sometimes those offending frequencies are what help you cut in a mix. "Offensive" is also relative, to the mix or context you're working in. This is the difficulty of creating something in isolation then trying to adapt it to your preferred use case. I remember Petrucci saying something like "if you cut all of undesirable parts of a guitar tone out, you'll be left with nothing". Of course I'm paraphrasing, but it is important to distinguish between offensive or nasty frequencies that help you stand out in a mix, and the offensive or nasty frequencies (i.e., resonances like "whistles") that your tone and mix would do better without.
Sometimes those offending frequencies are what help you cut in a mix. "Offensive" is also relative, to the mix or context you're working in. This is the difficulty of creating something in isolation then trying to adapt it to your preferred use case. I remember Petrucci saying something like "if you cut all of undesirable parts of a guitar tone out, you'll be left with nothing". Of course I'm paraphrasing, but it is important to distinguish between offensive or nasty frequencies that help you stand out in a mix, and the offensive or nasty frequencies (i.e., resonances like "whistles") that your tone and mix would do better without.