This is always a challenge. I use a Strat, (2 patches) a Tele with P90's, (one Patch) and a Taylor T5 (one patch) for acoustic songs. Each guitar has it's own patches. Here's what I do. First, It's CRITICAL you do this exercise at performance volume. I take the guitar I use the most (Stat) and set that at a functional volume, including the solo boost volume. That means I ensure I'm not clipping (on the AX8 or my mixing board) in any way, when I use my Strat on Strat Patch Dirty. Then I look at the VU meter and take note of the level on the AX8. Then I do the same thing for my other guitars and patches, getting them as close as possible to Strat Patch Dirty. Always checking the VU meeter and my board. At this point, all guitars and patches are in the 'ballpark". When the band gets together, I have my AX8 hooked up to my laptop and while we play songs, I tweek the patches. I listen to the mix via the mains, NOT monitors. At this point I just want to be sure that my guitars and patches work for what the audience will here. From there, I'll focus on my monitor, etc. Hope this helps. Also, search the forum, there are great posts (Austin Buddy) on this topic. Look in Tips and Tricks.