Sometimes it's fun to have excess, and I put my POD X3 Live in the loop like that, but in presets, give it the entire top row of the matrix, and mix it in parallel with the AXE blocks. In these cases, the AXE-FX 2 is doing a lot of pitch-shifting, and the POD may be trying to keep up, and both are abusing some sort of fuzz circuit. As you might imagine, I mix and match the levels over time, and slowly realize that I should just stick to the AXE sound alone, and keep the X3 Live for unfortunate backup scenarios. Then I do that, and my tone improves. -but it was fun to experiment!