I didn't see a thread on the topic, so I thought I'd kick it off. I'm finding that that for my JB pickup, I like the Speaker Breakup set to Hard. It also plays nice with my low output single coil in the neck because it helps it stay a bit cleaner. I'm using a greenback imp. curve and cabs. My Thornbucker plus and EVH Frankie p/u's like the medium setting. I'm guessing it's like fine tuning a speakers wattage or maybe it's 'break in'. I'm only 20 minutes into the new firmware and playing with the parameters so I may have a completely different outlook in a few hours/days.