Here's an example preset with extreme gain settings that without the Gate set to SCSEL Input 1, you would have to set the threshold, so high that if you picked softly the notes would get cut off and you wouldn't get any sustain.
You may need to go into the Gate Block (GTE in Axe-Fx II, GateExp in Axe-Edit) and adjust the Threshold for your pickups. I tested with Humbucker and Single Coil pickups at high volumes and didn't get out of control feedback. You should be able to stay in the range between -80 to -70 and still have notes sustain without getting cut off. If you want a real tight choppy sound, adjust the Threshold to between -60 to -40 or higher.
Scene 1 is super metal high gain and Scene 2 is more of a rock high gain.
I don't ever use this much gain but used extreme settings to show how well the Gate works when set to Side Chain Input. If you want to hear how much noise the Gate is removing, try disabling the Gate but be careful because you will get tons of noise and feedback that may set off your smoke detectors and send any pets in the house running and hiding under your bed