Do it! I avoided anything that looked like a strat for most of my guitar playing life for 2 reasons:
1. Metallica didn't use them, at least not normally (lol)
2. I felt like I saw fender's brand name everywhere on things and all that merchandising turned me off.
Then the PRS silver sky came out and man oh man, the sounds people were getting out of them made me realize I really liked the strat sound. So I broke down and bought a used mexican fender strat. It is a great guitar for what it was mean for, which isn't necessarily metal. Mine is too noisy with the classic style single coils to play anything too high gain in my opinion.
Yeah, I regular go to preset 1, the 59 Bassman and the Strat and jam out!