I cleared all presets, did a reboot, reinstalled the "Factory Preset Banks A, B and C for CYGNUS Mar 8, 2022", tried to replace the Wah with the Looper in Layout and if the Out 1 Speaker is a bit about noon the loud short sound hearable and Out 1 and 2 show red.
REASON: Well, the preset is not the reason, it's the GEQ 1 and GEQ 4 I use (refer to signature). If I set it to Off there is no issue anymore. If I activate the parametic GEQ 1 and 4 again, I get again the red levels and sound. That's not good for my ears and possibly dangerous.