No but when setting the input level yo low it can induce distortion because the bit rate is too low.
Or something similar.
Cliff replied this when I said I had to turn input trim way down to try to get rid of the unwanted distortion.
So I guess I'll have to adjust when swapping guitars.
I just find this a bit odd but I guess it has something to do with getting the guitar signal in the highest possible "bit resolution" if I understand this correctly.
It also seems a bit tedious that, when for example you're in the middle of a performance, when switching guitars, you have to go to I/O, strum hard and set levels. Don't forget this can be noisy because of the digital pot.
With the Ultra I just adjusted it for the highest output.