The key parts are your various drive/gain stages and the delay configuration in each song.
My template (built on Axe FX II, with intention to port over to AX8) consists of a compressor, two low/med gain drives, amp/cab, two delay blocks (in parallel unless the patch calls for serial delays like 1/4 into dotted 8th), a parallel MultiDelay Plex Shift into a filter for shimmer (on the Axe FX II, I'd also put that chain into a fully wet reverb), and a parallel reverb at the end (Studio C with high modulation on X, Deep Space with high decay on Y).
Since I haven't had the chance to test this on the AX8, I also plan on keeping around 2-3 of my favorite analog drives with a loop switcher, to free up CPU if necessary.
Basically I only change the delay flavor, tempo, and modifiers in each preset (one preset per song). Most presets I'll have several scenes for different sections of the song, enabling/bypassing compression, drives, delays and shimmer as necessary.
Occasionally I'll add something entirely different that's necessary for the song. For example, this Sunday I'll have a preset for Paul Baloche's "O Come All Ye Faithful". I added a post-amp pitch block (Fixed Harmony) with the mix attached to my expression pedal, so toe down mixes in a major 3rd harmony on some of the lead lines.
For the amp, I've been really digging Deluxe Verb Vib, the recently tweaked AC30TB, and the Matchbox (Matchless) DC-30.